THE HISTAMINE HANDBOOK - AN INTERACTIVE GUIDE
You've searched for answers. You've tried everything suggested. Your body is still asking for more.
This guide is for what comes next.
WRITTEN & CREATED BY AN EXPERIENCED HEALTH PRACTITIONER WHO HAS LIVED EXPERIENCE OF M.E, PoTS &MCAS

Condensing years of
learning into a roadmap
that may save you those same years of confusion.


Fully interactive with clickable chapters, links products & information, embedded resources, studies, information, podcasts, videos, protocols.
Do you have Myalgic Encephalomyelitis (M.E.), POTS, Long Covid, or Fibromyalgia—or a diagnosis of MCAS or histamine 'intolerance'?
Do you have symptoms that swing from calm to chaos?
Do you have fatigue, Post Exertional Malaise (PEM), exercise intolerance, muscle pain and weakness, skin flushing, skin rashes, heart palpitations, trouble standing, food intolerances, trouble sleeping, itching at night, reactions to smells, light and sounds?
Are you wanting to stop being bounced around the medical system, being dismissed and told your blood are fine so you must be fine....
Or simply told that there's nothing that can be done to help you.
Do you want to take back control?
If the answer is yes, then you are in the right place.
YOU are the person I have written this guide for.
I'm here to help empower you by giving you the knowledge and tools (and motivation!) to help get your light back. Find out more about Jo by clicking on her picture.
I’m Jo — Health Practitioner, Educator & Nutrition Specialist and founder of
GlowithJo Health + GloHome.
Whilst working for the NHS in 2014, I developed M.E and PoTs after a particularly nasty virus. After an almost full recovery in 2o17, I relapsed in 2022 following a traumatic event, significant life events and mould exposure in a new home. I went on to develop MCAS.
Using my professional insights and experience plus endless forensic research and being a human guinea pig (!), I've navigated my way back to better health.
As a health practitioner, I have spent decades helping people optimise their health. I created this handbook to hand over my knowledge and give you the clear, doable steps I wish I’d had twelve years ago!
My purpose is to shortcut someone else's healing journey by sharing what I have learnt.
What you’ll find inside this guide isn’t just theory, it’s the exact strategies, tools, and insights that can help you start improving your health today.
Instead of spending months (or years) drowning in forums, half-answers, and failed experiments, this guide gives you the roadmap I wish I’d had from day one.
I give you calm, doable (evidence based) steps to bring symptoms back under control.
This guide is jam packed with real information and tools I use with sensitive clients to calm the body, reduce stressors and steady the nervous system so you can feel more like you again.
This guide is designed for those who would love to work with a functional health practitioner but aren’t ready or able to invest in 1:1 sessions. It gives you the tools and information I use with clients, in a self-paced format that you can refer to again and again.
I realise that a lot of people can't access 1:1 support and wanted to address that by putting my expertise and knowledge into a guide instead.
170+ pages packed with lived experience learnings, strategies and step-by-step tools I use with clients.
A single consultation with a functional health practitioner costs in the region of £250+.
This guide contains what I'd walk you through over several sessions — and it's yours to return to whenever you need it.
IF YOU'D LIKE TO TAKE A LOOK INSIDE THE GUIDE AND GET MORE INFO BEFORE YOU BUY, SIMPLY CLICK THE LINK BELOW
Over 170 pages packed with learnings and insights
Written by a health practitioner who has lived experience of M.E, POTS & MCAS
20 years experience in the health field
Giving you back the power
What You’ll Get
✅ A “Start With WHY” approach
Understand why your symptoms may be happening — not just what to take for them. This guide explores histamine, mast cells, neuroinflammation, hormones, gut dysfunction, stress physiology, toxic load and nervous system dysregulation as connected pieces of the same puzzle.
✅ My Stages of Healing Framework
A practical framework to help you stop throwing random things at the wall and instead work within clear stages including Removal, Stabilisation, Repair and Restore — understanding what to focus on first, what order things may need addressing in and why timing matters.
✅ Histamine, mast cells & symptom patterns explained
A deep dive into histamine, mast cells, mast cell degranulation, autonomic dysfunction and neuroinflammation — and why symptoms can show up as anxiety, brain fog, insomnia, adrenaline surges, dizziness, temperature dysregulation, gut issues, pain, fatigue and food reactions.
✅ Food — without food fear
Low histamine and autoimmune principles, the F.A.T.T Method, histamine liberators, lectins, oxalates, nightshades, AIP, phased protocols, reintroductions and practical ways to calm inflammation without becoming terrified of every ingredient on the planet.
✅ Gut health, microbiome repair & digestive dysfunction
Leaky gut, SIBO, fermentation issues, low motility, digestive support, bone broth, microbiome rebuilding and understanding how gut dysfunction may be driving histamine overload.
✅ Hormones, perimenopause & HRT
The histamine–oestrogen connection, cortisol, stress hormones, luteal phase changes, perimenopause and why many women suddenly become more reactive during hormonal shifts.
✅ Detoxification, methylation & reducing the inflammatory load
Cellular hydration, electrolytes, binders, methylation, FIR saunas, sweating, lymphatic support and gentle detoxification approaches designed for sensitive systems.
✅ Supplements, medications & therapeutic tools explained simply
Antihistamines, mast cell stabilisers, LDN, quercetin, luteolin, bromelain, DAO support, key nutrients, supplement introduction protocols, therapeutic compounds and what to avoid during highly reactive phases.
✅ Home environment, air quality & personal care products
Mould, indoor air quality, air filters, fragrance sensitivity, perfume, cleaning products, mattresses, textiles, toothpaste, clothing and practical ways to reduce the burden of modern toxic load on the body.
✅ Nature, grounding & nervous system regulation
First morning light, grounding, sunlight, movement, pacing, sleep support, nervous system safety and reconnecting the body with the environment it evolved within.
✅ Do’s, Don’ts & “Epic Fails”
The mistakes I made so you hopefully don’t have to — including mould exposure, overdoing detox, supplement overload, pushing too hard, ignoring stress physiology and other lessons learned the hard way over 12 years.
✅ Product recommendations galore plus tools & supportive resources
Including clickable links throughout to products, supplements, studies, books, podcasts and resources that I personally use, rate or have found genuinely helpful.
✅ Jo's personal story woven throughout
This is not a dry textbook written by somebody who has only studied these conditions academically. My own journey with M.E., PoTS, MCAS, mould illness, nervous system dysfunction, relapse, recovery and rebuilding is woven throughout the guide in a very real, honest and human way.
✅ Frameworks for weaving it all together
Not just random tips and hacks — but a practical, phased approach to helping you understand how all the pieces connect together so you can begin supporting your body more intelligently and less overwhelmingly.
✅ Glimmers, hope & emotional resilience
A powerful final section on mindset, perspective, nervous system safety, emotional wellbeing, purpose, “glimmers” and learning to look for the light again whilst navigating complex health conditions.
✅ Interactive & fatigue-friendly by design
Created specifically for people with fatigue and cognitive dysfunction, with clickable chapters, embedded links, return-to-menu buttons and supportive pacing throughout.
✅ Professional knowledge + lived experience
Written by Jo Redfearn — Nutrition Specialist, Health Educator and someone who has personally navigated over 12 years of M.E., PoTS, MCAS, histamine overload and nervous system dysfunction herself.
How this helps?
✅ Gives you the WHY behind every aspect. Symptoms, supplements, food etc...
✅ Guides you through frameworks so you can choose what works for YOU.
✅ Written and created by someone who’s lived it.
Is this you?
✅ Diagnosis of M.E., POTS, Long Covid, or Fibromyalgia, MCAS or Histamine Intolerance??
✅ “Wired but tired,” brain fog, racing heart, gut drama, itch/flush, headaches, sleep that won’t behave.
✅ Reactions that feel random. One day you’re fine; the next, everything sets you off.
✅ Relentless fatigue and inflammation
✅ Only being able to eat a small number of "safe" foods
✅Unable to tolerate perfume or chemicals
✅ You want clear, gentle steps that help without blowing up your routine (or budget).
FAQs
Q. Is this medical advice?
A. No. It’s educational guidance to help you make informed choices. Use what fits your body and circumstances. Consult your GP or health practitioner before making any changes.
Q. Are there rules?
A. No strict rules. I empower you with information so that you can lower histamine load, immune reactions adn inflammation with smart, gentle tweaks—better, not perfect.
Q. How do I get it?
A. Instant PDF download available after purchase on the site. Works on phone, tablet, or laptop. Print off for off screen reading and highlighting / turning down pages. Download available for 1 month after purchase.
MORE TESTIMONIALS....
Georgie, Bexhill
"Within a few weeks of following the steps in Jo’s guide, I noticed fewer flare‑ups and more energy. The practical tweaks were exactly what I needed and some 'who knew!' info"
Ruth, Cardiff
"I’ve been living with M.E. and POTS for years. This handbook finally gave me an understanding of my symptoms. It’s like having a mini-consult with Jo, but on my own schedule."
Benji, London
"After struggling with long Covid and MCAS, this guide helped me connect the dots between histamine and my symptoms. I wish I’d had it sooner.”
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